Izinto ezingavuthiwe ezihlanzekile i-Thymosin Beta 4 TB500/ TB-500 incezu cas 885340-08-9

I-TB500 iyi-molecule yokwenziwa endaweni esebenzayo ye-thymosin beta 4. I-TB500 ikhuthaza ukuhlukaniswa kwamaseli e-endothelial, i-angiogenesis kuzicubu ze-dermis, ukufuduka kwamaseli, ukufakwa kwe-collagen nokunciphisa ukuvuvukala.Chaza i-angiogenesis (ANG), iphrotheni engu-14,124 Da ehambisana ne-angiogenesis ekuqhubekeleni phambili kwesimila.Ifihliwe ngamaseli e-tumor, angama-inducers asebenzayo okwakhiwa kwemithambo yegazi emisha.
Izici zesakhiwo Acharya et al.inqume ukwakheka kwekristalu kwama-antigens abantu kokuthi 2.4 0 A. Isakhiwo sisonke sinemigoqo ephindwe kathathu emise okwezinso okusikhumbuza i-RNaseA.Isikhungo somsebenzi we-RNA lysis (I-His-13, i-His-114 ne-Lys-40) kanye nezingosi zokuzibophezela ze-receptor, imisebenzi emibili ebalulekile ye-biological ebambe iqhaza ihlukile ku-Rnase A 5. Ingqikithi emaphakathi ye-molecule iqukethe ipheya ye-P- izakhiwo ezinokuhlanekezela okuphambene nokuhambisana, ezakha i-topology eyinhloko, enesisekelo esiyinsalela i-Ser-72 ne-Gly-99 kuma-vertices.Isakhiwo esikhulu esixegayo sigcwaliswa ngamaketanga amabili engeziwe nhlangothi zombili zala maketango amaphakathi (asele 41-47; 111-116).Kukhona i-helix H1 engu-3, ​​i-3-14 esele, i-H2, i-22-33 ne-H3 esele, kanye ne-49-58 esele.