Ukweqisa ngokweqile kwandisa ingozi yokugcinwa kwamanzi kanye ne-hyponatremia.Ukulawulwa kwe-hyponatremia kuyahlukahluka kumuntu nomuntu.Ezigulini ezine-hyponatremia engeyona uphawu, i-desmopressin kufanele iyekwe futhi kuvinjelwe ukuphuza uketshezi.Ezigulini ezine-symptomatic hyponatremia, kungakuhle ukuthi kufakwe i-isotonic noma i-hypertonic sodium chloride ku-drip.Ezimweni ezinzima zokugcinwa kwamanzi (amajaqamba nokulahlekelwa ukwazi), ukwelashwa nge-furosemide kufanele kwengezwe.
Iziguli ezinokoma okuvamile noma kwengqondo;i-angina pectoris engazinzile;ukungasebenzi kahle kwe-metabolic kwenhliziyo;uhlobo IIB vascular hemophilia.Ukunakwa okukhethekile kufanele kukhokhwe engozini yokugcinwa kwamanzi.Ukudla okusaketshezi kufanele kwehliswe kube kuncane ngangokunokwenzeka futhi isisindo kufanele sihlolwe njalo.Uma kukhona ukwanda kancane kancane kwesisindo somzimba kanye ne-sodium yegazi yehla ngaphansi kuka-130 mmol/L noma i-plasma osmolality iwela ngaphansi kuka-270 mosm/kg, ukuphuza uketshezi kufanele kwehliswe kakhulu futhi iyekwe i-desmopressin.Sebenzisa ngokuqapha ezigulini ezincane kakhulu noma asebekhulile;ezigulini ezinezinye izifo ezidinga ukwelashwa nge-diuretic ngokungalingani koketshezi kanye/noma kokuncibilika;kanye nasezigulini ezisengozini yokwanda kwengcindezi ye-intracranial.Izici ze-coagulation kanye nesikhathi sokopha kufanele kulinganiswe ngaphambi kokusebenzisa lesi sidakamizwa;ukugxila kwe-plasma kwe-VIII:C kanye ne-VWF:AG kukhuphuka kakhulu ngemva kokuphathwa, kodwa akukwazanga ukuthola ukuhlobana phakathi kwamazinga e-plasma alezi zici kanye nesikhathi sokopha ngaphambi nangemva kokuphathwa.Ngakho-ke uma kungenzeka, umphumela we-desmopressin ngesikhathi sokopha esigulini ngasinye kufanele unqunywe ngokuhlolwa.
Ukunqunywa kwesikhathi sokopha kufanele kulinganiswe ngokusemandleni, isb, ngendlela ye-Simplate II.Imithelela Ekukhulelweni Nokuncelisa Ukuhlolwa kokuzala kumagundane nakonogwaja okulawulwa izikhathi ezingaphezu kwekhulu kumthamo womuntu kubonise ukuthi i-desmopressin ayiwulimazi umbungu.Omunye umcwaningi ubike izehlakalo ezintathu zokukhubazeka ezinganeni ezizalwa abesifazane abakhulelwe abasebenzisa i-desmopressin ngesikhathi sokukhulelwa, kodwa eminye imibiko yamacala angaphezu kuka-120 iye yabonisa ukuthi izinsana ezizalwa abesifazane abasebenzisa i-desmopressin ngesikhathi sokukhulelwa zazivamile.
Ngaphezu kwalokho, ucwaningo olubhalwe kahle alukhombisi ukwanda kwezinga lokukhubazeka kokuzalwa ezinganeni ezingu-29 ezizalwa abesifazane abakhulelwe abasebenzisa i-desmopressin phakathi nesikhathi sonke sokukhulelwa.Ukuhlaziywa kobisi lwebele oluvela kwabesifazane abahlengikazi abalashwa ngemithamo ephezulu (300ug intranasal) kwabonisa ukuthi inani le-desmopressin elidluliselwa enganeni lalingaphansi kakhulu kunenani elidingekayo ukuze kuthinteke i-diuresis kanye ne-hemostasis.
Amalungiselelo: Izidakamizwa ezilwa nokuvuvukala zingathuthukisa impendulo yesiguli ku-desmopressin ngaphandle kokwandisa isikhathi sayo sokusebenza.Ezinye izinto ezaziwa ngokukhulula amahomoni e-antidiuretic, njenge-tricyclic antidepressants, i-chlorpromazine, ne-carbamazepine, zenza umphumela we-antidiuretic.Yandisa ingozi yokugcinwa kwamanzi.
Isikhathi sokuthumela: Jan-23-2024